Researchers at Cedars-Sinai have found that senescent cells use the protein PD-L2 to evade immune clearance. When scientists blocked or removed PD-L2 in mice, the animals showed reduced accumulation of these aging cells, lower inflammation, and improvements in grip strength and blood sugar processing.
The mechanism points to a concrete target for clearing out lingering cells that drive age-related decline. Still, moving from mouse models to human therapy is a long path, and we do not yet know if blocking PD-L2 is safe or effective in people.
more: https://www.sciencedaily.com/releases/2026/10/261013015800.htm
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