Researchers at UC Santa Cruz observed that psilocybin rapidly forms and matures neural connections while removing older ones in mice. Using two-photon microscopy, they tracked these structural changes over several weeks to confirm active synaptic remodeling. The study identified a specific group of cortical neurons responsible for this rewiring process.
The team successfully separated these cellular changes from the behavioral responses linked to hallucinations, suggesting therapeutic neuroplasticity might be achievable without the psychedelic state. This paves the way for drugs that enhance brain adaptability for conditions like depression without the associated perceptual disturbances. However, results are currently limited to mice, and the drug’s impact varies depending on prior chronic stress exposure.
more: https://www.sciencedaily.com/releases/2026/11/261104012308.htm
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