Mediarium: A single-container replacement for the ARR stack

11 10 2026
Mediarium: A single-container replacement for the ARR stack

Mediarium is a new self-hosted Docker container that combines Radarr, Sonarr, Prowlarr, SABnzbd, a torrent client, and Bazarr into one application. It handles search, download, unpacking, and library organization for movies, TV, music, ebooks, and audiobooks on 64-bit Linux servers and NAS hardware. You can migrate existing setups from the traditional multi-container stack without rewriting your library paths.

It is worth testing if you are tired of maintaining half a dozen interconnected services and want a unified configuration file and search bar. However, the project is young and still has rough edges, so production users with complex automation rules should stick with the individual ARR tools for now. Check the documentation for known limitations before moving a primary library over.

more: https://github.com/rdborg/Mediarium

my other side: ivo.blogspot.com





HIIT maintains muscle while older adults lose fat

10 10 2026

A six-month trial of 123 adults averaging 72 years old compared high, moderate, and low-intensity exercise. While all three groups lost modest amounts of fat, only the high-intensity interval training retained lean tissue; moderate training caused a slight decline in muscle mass alongside fat loss.

The distinction matters because preserving lean tissue is critical for physical independence in later life, though the scans measured tissue mass rather than actual strength improvements. The researchers also noted that the overall differences were relatively small and caution against overstating the clinical impact.

more: https://www.sciencedaily.com/releases/2026/10/261007233348.htm

my other side: ivo.blogspot.com





Pre-surgery immunotherapy shows durable bowel cancer control

10 10 2026

A small clinical trial found that nine weeks of the immunotherapy drug pembrolizumab before surgery resulted in zero cancer recurrences after 33 months in patients with a specific genetic profile of bowel cancer. Traditionally, about a quarter of patients treated with standard surgery and chemotherapy relapse within three years. The researchers also used personalized blood tests to track tumor DNA and identify who responded best to the treatment.

The mechanism here relies on a particular genetic subtype, MMR-deficient and MSI-high tumors, which represent only about ten to fifteen percent of stage two and three bowel cases. The trial was small, following just 32 patients, so these results need replication in larger cohorts before shifting standard clinical practice. It is a promising shift toward pre-operative treatment, but one that applies to a narrow biological window rather than all bowel cancers universally.

more: https://www.sciencedaily.com/releases/2026/10/261007042115.htm

my other side: ivo.blogspot.com





Aurelio: Self-hosted wealth management and financial planning

10 10 2026
Aurelio: Self-hosted wealth management and financial planning

Aurelio is a local-first financial planning app that tracks your accounts, portfolios, debts, and cash flow in a single SQLite database. It requires Node.js 22 and uv, runs locally via shell scripts, and stores records in backend/data.db. The optional AI advisor connects through OpenRouter using your own API key to answer questions and propose data changes.

It is worth a look if you want complete control over your financial data without SaaS subscriptions or cloud lock-in. The catch is the setup friction and the fact that AI-driven features like portfolio analysis cost real money per query and require manual validation. Skip it if you just want a hands-off spreadsheet or a plug-and-play bank aggregator.

more: https://github.com/LosaLosSantos/aurelio-finance

my other side: ivo.blogspot.com





MacMiniMode keeps lid-closed MacBooks awake on power

10 10 2026
MacMiniMode keeps lid-closed MacBooks awake on power

MacMiniMode is a signed macOS package that runs on Apple Silicon or Intel systems requiring macOS 12 or later. It automates clamshell mode without requiring an external display, dummy HDMI plug, or manual terminal commands like caffeinate. When plugged into AC power, it disables sleep with the lid closed; when unplugged, it reverts to normal battery sleep behavior.

It is worth installing if you use an older MacBook as a headless home server and are tired of managing power states manually. The catch is that it solves a very narrow workflow problem and can conflict with third-party cleaner utilities or remote desktop tools that aggressively rewrite power settings. If you only use your laptop as a portable machine, you have no use for it.

more: https://github.com/Pama-Lee/MacMiniMode

my other side: ivo.blogspot.com





How five plant compounds affect cancer cells

9 10 2026
How five plant compounds affect cancer cells

Researchers at Wroclaw Medical University tested five plant-derived substances—including curcumin and berberine—on fibrosarcoma cells and healthy muscle cells. Curcumin caused the share of senescent cancer cells to rise from roughly 16 percent to over 75 percent while disrupting mitochondrial energy production and dropping cancer cell ATP levels by up to 92 percent.

The study is a useful reminder that high lab activity means little without selectivity and a tolerable safety profile, as shown by the high toxicity of biochanin A in wax moth larvae. These are early in vitro and invertebrate results, so they tell us very little about clinical utility in humans yet.

more: https://www.sciencedaily.com/releases/2026/10/261006234531.htm

my other side: ivo.blogspot.com





Bacterial immune systems use viral enzymes as alarms

9 10 2026
Bacterial immune systems use viral enzymes as alarms

Researchers studying bacterial CBASS immune systems found that certain phages trigger a defense response by using proteases that cleave host sensor proteins. Rather than detecting viral genetic material directly, the bacteria recognize the damage caused by the invader's own enzymes. This activation mechanism forces an infected cell to commit suicide, preventing the virus from spreading to neighboring cells.

This discovery matters because CBASS shares an evolutionary ancestor with innate immune pathways found in humans. While it could eventually help engineers improve phage therapies against resistant bacteria, the immediate value is purely foundational. We are looking at a billion-year-old logic for detecting cellular damage that still operates inside our own bodies today.

more: https://www.sciencedaily.com/releases/2026/10/261007042100.htm

my other side: ivo.blogspot.com





Pond organism rewrites the standard genetic code

9 10 2026
Pond organism rewrites the standard genetic code

While testing a single-cell sequencing method on a pond protist, researchers found that the microscopic organism uses two standard stop codons to build amino acids instead. This breaks a long-held biological assumption that the genetic translation pattern is largely fixed across evolution. The discovery came entirely by chance from an unidentified ciliate collected in an Oxford park.

It is a humbling reminder of how little we actually know about the genetic diversity hiding in simple pond water. While protists are notoriously difficult to generalize, finding a working organism that ignores standard translation rules suggests the microscopic world holds many more structural surprises. We should expect more exceptions to foundational biology as sequencing tools improve and we look closer.

more: https://www.sciencedaily.com/releases/2026/10/261007233136.htm

my other side: ivo.blogspot.com





Distilling custom local models using agentic prompt workflows

9 10 2026
Distilling custom local models using agentic prompt workflows

Yuvraj Sharma and Abubakar Abid describe using an agentic HuggingChat tool called ML-intern to turn large models into tiny, CPU-runnable custom variants. For sixteen dollars of compute, the system takes an initial prompt and dataset, handles training and evaluation on Hugging Face hardware, and outputs models like a 0.8B Qwen-Image rewriter that replaces a 20GB teacher model. The process relies on detailed specification prompts that enforce baseline testing and strict budget limits.

It is worth trying if you routinely need task-specific models that fit on local hardware without paying API fees. The catch is that the output quality depends entirely on writing structured prompts up to two thousand words long, including verified facts and smoke tests. If you prefer turnkey tooling or do not want to curate training datasets, skip this approach.

more: https://huggingface.co/blog/building-with-ml-intern

my other side: ivo.blogspot.com





Magpie runs a local AI translation and routing gateway

9 10 2026
Magpie runs a local AI translation and routing gateway

Magpie is a cross-platform menu bar app and local proxy that unifies dozens of AI coding agents behind standard wire APIs. It translates between OpenAI, Anthropic, and Gemini formats on localhost while managing quotas across multiple accounts and subscription logins. Instead of editing separate JSON config files for every tool, you pick a model from a list and the gateway handles failover automatically when limits hit.

It is worth installing if you juggle multiple CLI agents and paid accounts, saving you from manually rotating API keys when quotas run out mid-task. The catch is that routing traffic through an extra local proxy adds another moving part to debug when requests fail or tokens do not match up. Skip it if you only use a single official client and standard API keys without hitting limits.

more: https://github.com/yetone/magpie

my other side: ivo.blogspot.com